产品
编 号：F749204
分子式：C19H19N5O2
分子量：349.39
分子式：C19H19N5O2
分子量：349.39
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2132411-21-1
产品详情
生物活性：
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis.
体外研究：
QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX. QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis.
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis.
体外研究：
QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX. QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis.
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