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编 号：F749102
分子式：C22H32ClN3O6S2
分子量：534.09
分子式：C22H32ClN3O6S2
分子量：534.09
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CAS No: 211558-19-9
产品详情
生物活性：
Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.
体内研究：
Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice.Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria.Animal Model:KM mice weighing 18–22 g
Dosage:2.89, 3.40 and 4.00 g/kg
Administration:Oral administration (tablet), once
Result:Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.
Animal Model:ICR mice, sepsis mouse models
Dosage:50 and 100 mg/kg
Administration:Oral administration (tablet), once
Result:Significantly increased the survival number of the sepsis mice within a 168 h observation period.
体外研究：
Tebipenem pivoxil hydrochloride (0-128 μg/mL, 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria.
Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.
体内研究：
Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice.Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria.Animal Model:KM mice weighing 18–22 g
Dosage:2.89, 3.40 and 4.00 g/kg
Administration:Oral administration (tablet), once
Result:Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.
Animal Model:ICR mice, sepsis mouse models
Dosage:50 and 100 mg/kg
Administration:Oral administration (tablet), once
Result:Significantly increased the survival number of the sepsis mice within a 168 h observation period.
体外研究：
Tebipenem pivoxil hydrochloride (0-128 μg/mL, 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria.
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