产品
编 号：F749055
分子式：C24H21FN2O4
分子量：420.43
分子式：C24H21FN2O4
分子量：420.43
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CAS No: 210346-40-0
产品详情
生物活性：
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells.
体外研究：
Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively.Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51.
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells.
体外研究：
Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively.Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51.
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