产品
编 号：F749033
分子式：C25H25N5O
分子量：411.5
分子式：C25H25N5O
分子量：411.5
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2102194-04-5
产品详情
生物活性：
MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent.
体内研究：
[11C]MK-6884 (compound 13) shows non-displaceable binding potential (BPND) of 0.83 in rhesus monkeys.[11C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain.[11C]MK-688 can penetrate the blood-brain barrier in monkeys.
体外研究：
MK-6884 (compound 13; 0-22 μM) is a PAM of ACh function in a cell-based Ca2+ mobilization assay, with an EC50 of 27 nM.
MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent.
体内研究：
[11C]MK-6884 (compound 13) shows non-displaceable binding potential (BPND) of 0.83 in rhesus monkeys.[11C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain.[11C]MK-688 can penetrate the blood-brain barrier in monkeys.
体外研究：
MK-6884 (compound 13; 0-22 μM) is a PAM of ACh function in a cell-based Ca2+ mobilization assay, with an EC50 of 27 nM.
产品资料
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