产品
编 号：F748986
分子式：C28H24FN7O3
分子量：525.53
分子式：C28H24FN7O3
分子量：525.53
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规格
价格
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结构图
CAS No: 2098639-70-2
产品详情
生物活性：
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1?/?) and Capan-1 (BRCA2?/?) cells with IC50 values below 0.3 nM.
体外研究：
PARP1-IN-14 (compound 19k) 显著抑制耐药 Capan-1 细胞的增殖 (IC50 .PARP1-IN-14（0-1 μM，0-48 小时）可诱导亲代细胞和耐药细胞的细胞周期停滞和凋亡。
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1?/?) and Capan-1 (BRCA2?/?) cells with IC50 values below 0.3 nM.
体外研究：
PARP1-IN-14 (compound 19k) 显著抑制耐药 Capan-1 细胞的增殖 (IC50 .PARP1-IN-14（0-1 μM，0-48 小时）可诱导亲代细胞和耐药细胞的细胞周期停滞和凋亡。
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