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编 号：F748948
分子式：C19H15N3O2
分子量：317.34
分子式：C19H15N3O2
分子量：317.34
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CAS No: 2097497-16-8
产品详情
生物活性：
Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models.
体内研究：
Anticancer agent 109 (3 mg/kg，腹腔注射，A549 肿瘤模型 3 1天，PANC-1 肿瘤模型 85 天，每周 6 次) 在裸鼠异种移植模型中显著降低肿瘤的大小和重量。Animal Model:A549 or PANC-1 xenografted in BALB/c-nu mice.
Dosage:1 mg/kg; 3 mg/kg
Administration:Intraperitoneal injection (i.p.) 6 times a week
Result:Promoted tumor regression to around a quarter with 1 mg/kg, smaller but not eliminated with 3 mg/kg in A549 models.Promoted tumor regression to around a quarter with 3 mg/kg in PANC-1 models.
体外研究：
Anticancer agent 109 (10 μM，48 小时) 抑制 A549 细胞 Gas6 和 Axl，抑制 PANC-1 细胞 Gas6-Axl 轴相关蛋白，诱导 G1 期阻滞并促进晚期凋亡，但不改变 DNA 合成。
Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models.
体内研究：
Anticancer agent 109 (3 mg/kg，腹腔注射，A549 肿瘤模型 3 1天，PANC-1 肿瘤模型 85 天，每周 6 次) 在裸鼠异种移植模型中显著降低肿瘤的大小和重量。Animal Model:A549 or PANC-1 xenografted in BALB/c-nu mice.
Dosage:1 mg/kg; 3 mg/kg
Administration:Intraperitoneal injection (i.p.) 6 times a week
Result:Promoted tumor regression to around a quarter with 1 mg/kg, smaller but not eliminated with 3 mg/kg in A549 models.Promoted tumor regression to around a quarter with 3 mg/kg in PANC-1 models.
体外研究：
Anticancer agent 109 (10 μM，48 小时) 抑制 A549 细胞 Gas6 和 Axl，抑制 PANC-1 细胞 Gas6-Axl 轴相关蛋白，诱导 G1 期阻滞并促进晚期凋亡，但不改变 DNA 合成。
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