产品
编 号：F748844
分子式：C16H21ClN2O2
分子量：308.8
分子式：C16H21ClN2O2
分子量：308.8
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 209394-18-3
产品详情
生物活性：
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease. Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hydrochloride 在从青春期到产前压力大鼠的成年期的高架十字迷宫 (EPM) 和强迫游泳测试 (FST) 测试中，消除了他们的高度焦虑和抑郁样行为。Ladostigil (50 μmol/kg; single p.o.) hydrochloride 在大鼠物体识别测试中恢复丧失的情景记忆。Animal Model:Pathogen-free (SPF) Sprague-Dawley rats
Dosage:17 mg/kg
Administration:Oral (added to the drinking water) daily for 6 weeks
Result:Inhibited brain MAO-A and B by more than 60%.Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
体外研究：
Ladostigil (1-10 μM) hydrochloride 具有神经保护活性，包括防止线粒体膜电位 (ψ) 下降，衰减凋亡级联和抑制 OS 损伤诱导的 ROS 产生。Ladostigil (1-10 μM) hydrochloride 具有显著的神经保护活性，包括抑制 caspase-3 激活，诱导 Bcl-2，降低人成神经细胞瘤 SK-N-SH 细胞中 Bad 和 Bax 基因和蛋白的表达。
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease. Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) hydrochloride 在从青春期到产前压力大鼠的成年期的高架十字迷宫 (EPM) 和强迫游泳测试 (FST) 测试中，消除了他们的高度焦虑和抑郁样行为。Ladostigil (50 μmol/kg; single p.o.) hydrochloride 在大鼠物体识别测试中恢复丧失的情景记忆。Animal Model:Pathogen-free (SPF) Sprague-Dawley rats
Dosage:17 mg/kg
Administration:Oral (added to the drinking water) daily for 6 weeks
Result:Inhibited brain MAO-A and B by more than 60%.Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.
体外研究：
Ladostigil (1-10 μM) hydrochloride 具有神经保护活性，包括防止线粒体膜电位 (ψ) 下降，衰减凋亡级联和抑制 OS 损伤诱导的 ROS 产生。Ladostigil (1-10 μM) hydrochloride 具有显著的神经保护活性，包括抑制 caspase-3 激活，诱导 Bcl-2，降低人成神经细胞瘤 SK-N-SH 细胞中 Bad 和 Bax 基因和蛋白的表达。
产品资料
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