产品
编 号：F748841
分子式：C20H27N3O4
分子量：373.45
分子式：C20H27N3O4
分子量：373.45
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CAS No: 2093407-25-9
产品详情
生物活性：
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation.
体内研究：
KY-02327 (20 mg/kg; p.o.; 5 sequential days per week for 4 weeks) successfully rescues bone loss in the ovariectomized (OVX) mouse model.Animal Model:8-week-old female BL6 mice (ovariectomized (OVX)-induced osteoporosis model mice)
Dosage:20 mg/kg
Administration:P.o.; administered for 5 sequential days per week for 4 weeks
Result:Newly formed bones which labeled with calcein were decreased in the femur of vehicle‐treated OVX mice.
体外研究：
KY-02327 (1-10 μM; 2 days; MC3T3E1 cells, a murine pre-osteoblast cell line) increases β-catenin protein level together with Runx2 and accumulated nuclear β-catenin in a dose-dependent manner.KY-02327 (1-10 μM) increases the mRNA levels of osteoblast differentiation markers collagen 1a (Col1a) and osteocalcin (OCN).
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation.
体内研究：
KY-02327 (20 mg/kg; p.o.; 5 sequential days per week for 4 weeks) successfully rescues bone loss in the ovariectomized (OVX) mouse model.Animal Model:8-week-old female BL6 mice (ovariectomized (OVX)-induced osteoporosis model mice)
Dosage:20 mg/kg
Administration:P.o.; administered for 5 sequential days per week for 4 weeks
Result:Newly formed bones which labeled with calcein were decreased in the femur of vehicle‐treated OVX mice.
体外研究：
KY-02327 (1-10 μM; 2 days; MC3T3E1 cells, a murine pre-osteoblast cell line) increases β-catenin protein level together with Runx2 and accumulated nuclear β-catenin in a dose-dependent manner.KY-02327 (1-10 μM) increases the mRNA levels of osteoblast differentiation markers collagen 1a (Col1a) and osteocalcin (OCN).
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