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编 号:F748733
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1mg
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5mg
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生物活性:
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors.

体内研究:
CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models.

体外研究:
CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range.CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines.
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