产品
编 号:F748733
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结构图
CAS No: 2085844-54-6
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产品详情
生物活性:
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors.
体内研究:
CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models.
体外研究:
CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range.CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines.