产品
编 号：F748710
分子式：C25H29ClF2N4O5
分子量：538.97
分子式：C25H29ClF2N4O5
分子量：538.97
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 208109-39-1
产品详情
生物活性：
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.
体内研究：
In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in theforced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels.F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%.F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats.
体外研究：
F13714 targets 5-HT1A autoreceptors.
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.
体内研究：
In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in theforced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels.F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%.F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats.
体外研究：
F13714 targets 5-HT1A autoreceptors.
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