产品
编 号：F748704
分子式：C35H43ClF4N6O8
分子量：787.2
分子式：C35H43ClF4N6O8
分子量：787.2
产品类型
规格
价格
是否有货
1mg
询价
询价
2mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2080306-25-6
产品详情
生物活性：
HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling.
体外研究：
HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells.HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells.HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells.HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells.
HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling.
体外研究：
HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells.HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells.HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells.HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备