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编 号：F748700
分子式：C19H17N3O4S
分子量：383.42
分子式：C19H17N3O4S
分子量：383.42
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CAS No: 2079895-60-4
产品详情
生物活性：
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM).
体内研究：
AM-1488 (oral gavage; 20 mg/kg; once) treatment significantly reverse mechanical allodynia induced by nerve injury in a mouse model of neuropathic pain, without being confounded by sedation or motor side effects.Animal Model:Mouse model of spared nerve injury (SNI)
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once
Result:Produced a significant 94% reversal of tactile allodynia, and the unbound brain concentration was 2.8- and 1.6-fold higher than the mouse GlyRα1 and GlyRα3 EC50 values, respectively.
Animal Model:Naive mice
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once
Result:Showed not significantly different from mice treated with vehicle.
体外研究：
AM-1488 also potentiates native GlyRs in mouse spinal-cord neurons, which express mostly GlyRα1(β) and GlyRα3(β).
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM).
体内研究：
AM-1488 (oral gavage; 20 mg/kg; once) treatment significantly reverse mechanical allodynia induced by nerve injury in a mouse model of neuropathic pain, without being confounded by sedation or motor side effects.Animal Model:Mouse model of spared nerve injury (SNI)
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once
Result:Produced a significant 94% reversal of tactile allodynia, and the unbound brain concentration was 2.8- and 1.6-fold higher than the mouse GlyRα1 and GlyRα3 EC50 values, respectively.
Animal Model:Naive mice
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once
Result:Showed not significantly different from mice treated with vehicle.
体外研究：
AM-1488 also potentiates native GlyRs in mouse spinal-cord neurons, which express mostly GlyRα1(β) and GlyRα3(β).
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