产品
编 号：F748699
分子式：C8H9IN2O5
分子量：340.07
分子式：C8H9IN2O5
分子量：340.07
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CAS No: 207920-87-4
产品详情
生物活性：
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis.
体外研究：
L-I-OddU (1 μM; H1 cells) inhibits Epstein-Barr virus (EBV) replication and decreases the linear form of EBV DNA.L-I-OddU (0.25-2 μM; 24 h; H1 and L5 cells) has a major metabolite is L-I-OddUMP and increases the amount of the mono- and diphosphate metabolites formed in H1 cells in a dose-dependent manner.
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis.
体外研究：
L-I-OddU (1 μM; H1 cells) inhibits Epstein-Barr virus (EBV) replication and decreases the linear form of EBV DNA.L-I-OddU (0.25-2 μM; 24 h; H1 and L5 cells) has a major metabolite is L-I-OddUMP and increases the amount of the mono- and diphosphate metabolites formed in H1 cells in a dose-dependent manner.
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