产品
编 号：F748680
分子式：C32H56N10O12
分子量：772.85
分子式：C32H56N10O12
分子量：772.85
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CAS No: 207392-60-7
产品详情
生物活性：
Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a Gi/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.
体内研究：
Intrathecal administration of Nocistatin (10 pg-1 μg) nociceptin or orphanin FQ (Noc/OFQ) induces pain responses including allodynia and hyperalgesia. Simultaneous administration of Nocistatin blocks the allodynia and hyperalgesia induced by Noc/OFQ. Nocistatin also attenuates the allodynia and hyperalgesia evoked by prostaglandin E2 and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin, and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses. Nocistatin counteracted the impairment of learning and memory induced by Noc/OFQ or scopolamine. Nocistatin is widely present in the spinal cord and brain. Although Nocistatin does not bind to the Noc/OFQ receptor, it binds to the membrane of mouse brain and spinal cord with a high affinity.
体外研究：
In the isolated organ bath studies Nocistatin (1 pM-1μM) inhibits the prostaglandin- and the KCl-evoked contractions in the uterus dose-dependently. Nocistatin, generated locally in the uterus, exerts an inhibitory effect, the mechanism being mediated in part by Ca2+-dependent K+ channels, the elevation of cAMP levels and sensory neuropeptides.
Nocistatin, a neuropeptide, is an endogenous ligand for the orphan opioid receptor-like receptor. Nocistatin is also a functional antagonist of neuropeptide nociceptin or orphanin FQ (Noc/OFQ). Nocistatin inhibits 5-HT release via a Gi/o proteinmediated pathway. Nocistatin blocks Nociceptin (Nociceptin)-induced allodynia and hyperalgesia.
体内研究：
Intrathecal administration of Nocistatin (10 pg-1 μg) nociceptin or orphanin FQ (Noc/OFQ) induces pain responses including allodynia and hyperalgesia. Simultaneous administration of Nocistatin blocks the allodynia and hyperalgesia induced by Noc/OFQ. Nocistatin also attenuates the allodynia and hyperalgesia evoked by prostaglandin E2 and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin, and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses. Nocistatin counteracted the impairment of learning and memory induced by Noc/OFQ or scopolamine. Nocistatin is widely present in the spinal cord and brain. Although Nocistatin does not bind to the Noc/OFQ receptor, it binds to the membrane of mouse brain and spinal cord with a high affinity.
体外研究：
In the isolated organ bath studies Nocistatin (1 pM-1μM) inhibits the prostaglandin- and the KCl-evoked contractions in the uterus dose-dependently. Nocistatin, generated locally in the uterus, exerts an inhibitory effect, the mechanism being mediated in part by Ca2+-dependent K+ channels, the elevation of cAMP levels and sensory neuropeptides.
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