产品
编 号：F748638
分子式：C31H44ClFN8O3
分子量：631.18
分子式：C31H44ClFN8O3
分子量：631.18
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2070014-95-6
产品详情
生物活性：
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic.
体内研究：
AP-III-a4 hydrochloride (ENOblock) (10 μM；96 h) 在斑马鱼中抑制癌细胞转移并抑制糖异生调节剂 PEPCK。Animal Model:The zebrafish cancer cell HCT116 xenograft model
Dosage:10 μM
Administration:96 h
Result:Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation.
体外研究：
AP-III-a4 hydrochloride (ENOblock) (0-10 μM；24 h) 以剂量依赖性方式抑制 HCT116 细胞活力。AP-III-a4 hydrochloride 直接结合到烯醇酶并抑制其活性。AP-III-a4 hydrochloride (0-10 μM；24 或 48 h) 抑制癌细胞迁移和侵袭，诱导癌细胞凋亡。AP-III-a4 hydrochloride (10 μM；24 h) 可诱导肝细胞和肾细胞摄取葡萄糖并抑制磷酸烯醇丙酮酸羧激酶 (PEPCK) 的表达。
AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic.
体内研究：
AP-III-a4 hydrochloride (ENOblock) (10 μM；96 h) 在斑马鱼中抑制癌细胞转移并抑制糖异生调节剂 PEPCK。Animal Model:The zebrafish cancer cell HCT116 xenograft model
Dosage:10 μM
Administration:96 h
Result:Reduced cancer cell dissemination. Inhibited PEPCK expression and induced glucose uptake. Inhibited adipogenesis and foam cell formation.
体外研究：
AP-III-a4 hydrochloride (ENOblock) (0-10 μM；24 h) 以剂量依赖性方式抑制 HCT116 细胞活力。AP-III-a4 hydrochloride 直接结合到烯醇酶并抑制其活性。AP-III-a4 hydrochloride (0-10 μM；24 或 48 h) 抑制癌细胞迁移和侵袭，诱导癌细胞凋亡。AP-III-a4 hydrochloride (10 μM；24 h) 可诱导肝细胞和肾细胞摄取葡萄糖并抑制磷酸烯醇丙酮酸羧激酶 (PEPCK) 的表达。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备