产品
编 号:F748590
产品类型
结构图
CAS No: 2058047-65-5
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产品详情
生物活性:
Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody. AMHRII is the anti-Müllerian hormone receptor. Murlentama significantly promotes macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Murlentama stimulates pro-inflammatory and anti-tumor internal environment, recruits and activates T cells. Murlentama suppresses tumors growth by inducing na?ve macrophage orientation and promoting tumor-associated macrophage (TAM) reprogramming.
体内研究:
Murlentamab (20 mg/kg;静脉注射;每周两次,持续 4 周) 在体内抑制小鼠肝癌 PDX 模型中的肿瘤生长。