产品
编 号：F748558
分子式：C47H77N3O11
分子量：860.13
分子式：C47H77N3O11
分子量：860.13
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规格
价格
是否有货
结构图
CAS No: 2055494-50-1
产品详情
生物活性：
LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway.
体内研究：
LM2I (2.5 mg/kg， 腹腔注射, 每隔一天共28天) 抑制了裸鼠异种移植瘤模型肿瘤的生长。Animal Model:Female athymic BALB/c nude mice xenograft model(injected subcutaneously into the flank region with HT29 cell).
Dosage:2.5 mg/kg/day
Administration:Intraperitoneal injection,every other day for 28 days
Result:The tumor weight was significantly lower than that of the control group, and the tumor cell density was lower.
体外研究：
LM2I (0μM~10μM, 48h)结直肠癌细胞系有较强的抑制作用。LM2I(2μM, 15d)在结直肠癌细胞中抑制EGFR通路。LM2I通过EGFR抑制结直肠癌癌症细胞。
LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway.
体内研究：
LM2I (2.5 mg/kg， 腹腔注射, 每隔一天共28天) 抑制了裸鼠异种移植瘤模型肿瘤的生长。Animal Model:Female athymic BALB/c nude mice xenograft model(injected subcutaneously into the flank region with HT29 cell).
Dosage:2.5 mg/kg/day
Administration:Intraperitoneal injection,every other day for 28 days
Result:The tumor weight was significantly lower than that of the control group, and the tumor cell density was lower.
体外研究：
LM2I (0μM~10μM, 48h)结直肠癌细胞系有较强的抑制作用。LM2I(2μM, 15d)在结直肠癌细胞中抑制EGFR通路。LM2I通过EGFR抑制结直肠癌癌症细胞。
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