产品
编 号：F748457
分子式：C17H24N2O
分子量：272.39
分子式：C17H24N2O
分子量：272.39
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CAS No: 2035203-91-7
产品详情
生物活性：
GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 μM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential.
体外研究：
GABAA receptor agent 4 (compound 1e) shows antagonist activity with IC50s of 4.95, 0.195, 0.250, 1.95, 2.18, 7.56, 0.56, 0.54 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively.GABAA receptor agent 4 (50 μM; 96 h) rescues inhibition of proliferation induced by alprazolam in both human PBMC and mouse splenocytes populations with minimal cell toxicity.
GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 μM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential.
体外研究：
GABAA receptor agent 4 (compound 1e) shows antagonist activity with IC50s of 4.95, 0.195, 0.250, 1.95, 2.18, 7.56, 0.56, 0.54 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively.GABAA receptor agent 4 (50 μM; 96 h) rescues inhibition of proliferation induced by alprazolam in both human PBMC and mouse splenocytes populations with minimal cell toxicity.
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