产品
编 号：F748396
分子式：C22H17F3N4O
分子量：410.39
分子式：C22H17F3N4O
分子量：410.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2022949-46-6
产品详情
生物活性：
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research.
体内研究：
Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology.Animal Model:APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides
Dosage:4 mg/kg
Administration:Orally gavage; twice per day; for 7 days
Result:Led to improved Y maze performance.
体外研究：
Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro.
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research.
体内研究：
Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology.Animal Model:APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides
Dosage:4 mg/kg
Administration:Orally gavage; twice per day; for 7 days
Result:Led to improved Y maze performance.
体外研究：
Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro.
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