产品
编 号：F748331
分子式：C18H18N2O3
分子量：310.35
分子式：C18H18N2O3
分子量：310.35
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CAS No: 2011784-91-9
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生物活性：
Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas.
体外研究：
Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%.Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells.Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88%.Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC50: 0.29 μΜ).
Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas.
体外研究：
Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%.Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells.Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88%.Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC50: 0.29 μΜ).
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