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编 号：F748299
分子式：C19H32N6O11S3
分子量：616.69
分子式：C19H32N6O11S3
分子量：616.69
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CAS No: 200393-05-1
产品详情
生物活性：
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti?proliferative, pro?apoptotic and anti?metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.
体内研究：
S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 1,4-butanedisulfonate 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为。S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 1,4-butanedisulfonate 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性。Animal Model:Valproic acid treated young mice
Dosage:30?mg/kg
Administration:p.o., for 3 days
Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
体外研究：
S-Adenosyl-L-methionine (300 μM, 24 或 48 h) 1,4-butanedisulfonate 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞。S-Adenosyl-L-methionine (300 μM, 24 h) 1,4-butanedisulfonate 减少 Cal-33 和 JHU-SCC-011 细胞的迁移。S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate 通过调节 DNMTs 的表达保护 5?FU 的抗癌作用。
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti?proliferative, pro?apoptotic and anti?metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.
体内研究：
S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 1,4-butanedisulfonate 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为。S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 1,4-butanedisulfonate 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性。Animal Model:Valproic acid treated young mice
Dosage:30?mg/kg
Administration:p.o., for 3 days
Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.
体外研究：
S-Adenosyl-L-methionine (300 μM, 24 或 48 h) 1,4-butanedisulfonate 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞。S-Adenosyl-L-methionine (300 μM, 24 h) 1,4-butanedisulfonate 减少 Cal-33 和 JHU-SCC-011 细胞的迁移。S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate 通过调节 DNMTs 的表达保护 5?FU 的抗癌作用。
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