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编 号:F748281
分子式:C25H21ClF3N5O2S
分子量:547.98
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生物活性:
Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD).

体内研究:
Zevaquenabant (3 mg/kg; p.o.; for 28 days) improves renal morphological and functional parameters in diet-induced obese mice.Animal Model:6-week-old male C57Bl/6J mice (diet-induced obesity)
Dosage:3 mg/kg
Administration:P.o.; for 28 days
Result:Improved kidney morphology and function in diet-induced obese mice.

体外研究:
Zevaquenabant can simultaneously inhibit CB1 receptors and inducible NOS in peripheral organs.
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