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编 号:F748216
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CAS No: 1987854-08-9
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生物活性:
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.
体内研究:
Bersanlimab(BI-505;20 mg/kg;腹腔注射;每周两次;持续 21 天)显着减少肿瘤生长并延长动物存活期。Animal Model:SCID mice injected with ARH-77 cells
Dosage:20 mg/kg
Administration:i.p.; twice-weekly; for 21 days
Result:Significantly reduced tumor growth and prolonged animal survival.
体外研究:
BI-505(1 ng/mL-1000 μg/mL)剂量依赖性地诱导表达 ICAM-1 的 Ramos、Raji 和 Daudi 淋巴瘤细胞的程序性细胞死亡 (PCD)。