产品
编 号：F748187
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规格
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是否有货
1mg
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询价
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CAS No: 1980787-47-0
产品详情
生物活性：
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
体内研究：
Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后，才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆，100% 无瘤小鼠被保护免于随后的肿瘤再攻击。Animal Model:Wild-type C57BL/6 and BALB/c mice
Dosage:2.4 mg/mouse, accompanied with anti-OX40 mAb (250 μg)
Administration:Intraperitoneal injection; 3 times per week for 3 weeks
Result:Inhibited tumor growth.Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
体外研究：
Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖，诱导凋亡。
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
体内研究：
Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后，才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆，100% 无瘤小鼠被保护免于随后的肿瘤再攻击。Animal Model:Wild-type C57BL/6 and BALB/c mice
Dosage:2.4 mg/mouse, accompanied with anti-OX40 mAb (250 μg)
Administration:Intraperitoneal injection; 3 times per week for 3 weeks
Result:Inhibited tumor growth.Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
体外研究：
Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖，诱导凋亡。
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