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编 号:F748099
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CAS No: 1957239-90-5
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生物活性:
Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity.
体内研究:
Bifikafusp alfa (1.43 and 4.29 MIU/kg; i.p.; daily; for 10 days; 雌性 NMRI 裸鼠 MiaPaca-A2 异种移植) 对已建立的胰腺癌具有抗肿瘤活性。Animal Model:Female NMRI nude mice with MiaPaca-A2 xenografts
Dosage:1.43 and 4.29 MIU/kg
Administration:Intraperitoneal injection; daily; for 10 days
Result:Reduced tumor volume to 21.4% (1.43 MIU/kg) and 2.7% (4.29 MIU/kg) compared with control mice.