产品
编 号：F076353
分子式：C22H28Cl2N4O
分子量：435.39
分子式：C22H28Cl2N4O
分子量：435.39
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
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10mg
询价
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25mg
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结构图
CAS No: 1217195-61-3
产品详情
生物活性：
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
体内研究：
CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models.Animal Model:Small human tumor xenografts in mice.
Dosage:100 mg/kg.
Administration:Orally twice daily for 7 days.
Result:Suppressed A375.S2 tumor growth by -50%.
体外研究：
CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells.CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells.
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
体内研究：
CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models.Animal Model:Small human tumor xenografts in mice.
Dosage:100 mg/kg.
Administration:Orally twice daily for 7 days.
Result:Suppressed A375.S2 tumor growth by -50%.
体外研究：
CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells.CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells.
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