产品
编 号：F747978
分子式：C15H18O4
分子量：262.3
分子式：C15H18O4
分子量：262.3
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CAS No: 1934299-51-0
产品详情
生物活性：
Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.
体内研究：
Eudebeiolide B (5 或 10 mg/kg 灌胃.，每天 1 次，持续 6 周) 在卵巢切除（OVX）小鼠模型中，可预防双侧卵巢切除 (OVX) 引起的骨质流失。Animal Model:Ovariectomized (OVX) mouse model
Dosage:5 or 10 mg/kg
Administration:After 6 weeks of ovarian resection, intragastric injection (i.g.) once daily for 6 weeks.
Result:Prevented bone mineral density (BMD) loss and bone mineral content (BMC) loss compared to the OVX mice.
体外研究：
Eudebeiolide B (1-30 μΜ，1 小时) 在小鼠骨髓巨噬细胞中抑制 RANKL 诱导的细胞分化，抑制破骨细胞生成相关标志基因的表达和 RANKL 介导的细胞信号传导。
Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.
体内研究：
Eudebeiolide B (5 或 10 mg/kg 灌胃.，每天 1 次，持续 6 周) 在卵巢切除（OVX）小鼠模型中，可预防双侧卵巢切除 (OVX) 引起的骨质流失。Animal Model:Ovariectomized (OVX) mouse model
Dosage:5 or 10 mg/kg
Administration:After 6 weeks of ovarian resection, intragastric injection (i.g.) once daily for 6 weeks.
Result:Prevented bone mineral density (BMD) loss and bone mineral content (BMC) loss compared to the OVX mice.
体外研究：
Eudebeiolide B (1-30 μΜ，1 小时) 在小鼠骨髓巨噬细胞中抑制 RANKL 诱导的细胞分化，抑制破骨细胞生成相关标志基因的表达和 RANKL 介导的细胞信号传导。
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