生物活性: Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.
体外研究: Bintrafusp alfa 可以赋予长期保护性免疫,降低调节性 T 细胞功能,显着增加 CD8+ T 细胞和自然杀伤细胞浸润,并减少肿瘤内骨髓来源的抑制细胞浸润。