产品
编 号：F747865
分子式：C22H19Cl2F3N6O3
分子量：543.33
分子式：C22H19Cl2F3N6O3
分子量：543.33
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结构图
CAS No: 1914998-56-3
产品详情
生物活性：
Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
体内研究：
Pecavaptan (0.01, 0.03, 0.1 and 0.3 mg/kg；静脉注射；单剂量) 在犬心动过速诱发的心力衰竭 (HF) 模型中保护免受精氨酸抗利尿激素 (arginine vasopressin, AVP) 介导的心输出量 (CO) 降低)。
Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
体内研究：
Pecavaptan (0.01, 0.03, 0.1 and 0.3 mg/kg；静脉注射；单剂量) 在犬心动过速诱发的心力衰竭 (HF) 模型中保护免受精氨酸抗利尿激素 (arginine vasopressin, AVP) 介导的心输出量 (CO) 降低)。
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