产品
编 号：F747864
分子式：C24H28N4O5
分子量：452.5
分子式：C24H28N4O5
分子量：452.5
产品类型
规格
价格
是否有货
结构图
CAS No: 1914944-54-9
产品详情
生物活性：
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM.
体内研究：
ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model.ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats. ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg).
体外研究：
ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x).
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM.
体内研究：
ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model.ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats. ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg).
体外研究：
ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC50 10.4 μM; hSERT/hROMK EP=612x).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备