产品
编 号：F747862
分子式：C24H26ClFN4O6
分子量：520.94
分子式：C24H26ClFN4O6
分子量：520.94
产品类型
规格
价格
是否有货
结构图
CAS No: 1914176-03-6
产品详情
生物活性：
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect.
体内研究：
AMPK activator 10 (化合物14d; 0.3, 1, 3 mg/kg; 口服灌胃; 一天2次; 21 天) 表现出降糖作用。 AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; 口服灌胃; 单剂量) 以剂量依赖性方式导致 ACC 的磷酸化水平升高，ACC 是 AMPK 的下游靶分子 。 AMPK activator 10 (0.5 mg/kg 静脉注射或 1.0 mg/kg 口服灌胃) 在大鼠中的 CL 为 9.02 mL/min?kg，Cmax 为 65.4 ng/mL，AUC 为 347 ng ?h/mL。 Animal Model:KKAy mice
Dosage:0.3, 1, 3 mg/kg
Administration:Orally; bid; for 21 days
Result:Exhibited a glucose lowering effect. The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group.
Animal Model:Rats
Dosage:0.5 mg/kg by iv or 1.0 mg/kg by po
Administration:IV or po
Result:Had a CL of 9.02 mL/min?kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng?h/mL.
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect.
体内研究：
AMPK activator 10 (化合物14d; 0.3, 1, 3 mg/kg; 口服灌胃; 一天2次; 21 天) 表现出降糖作用。 AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; 口服灌胃; 单剂量) 以剂量依赖性方式导致 ACC 的磷酸化水平升高，ACC 是 AMPK 的下游靶分子 。 AMPK activator 10 (0.5 mg/kg 静脉注射或 1.0 mg/kg 口服灌胃) 在大鼠中的 CL 为 9.02 mL/min?kg，Cmax 为 65.4 ng/mL，AUC 为 347 ng ?h/mL。 Animal Model:KKAy mice
Dosage:0.3, 1, 3 mg/kg
Administration:Orally; bid; for 21 days
Result:Exhibited a glucose lowering effect. The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group.
Animal Model:Rats
Dosage:0.5 mg/kg by iv or 1.0 mg/kg by po
Administration:IV or po
Result:Had a CL of 9.02 mL/min?kg, a Cmax of 65.4 ng/mL and an AUC of 347 ng?h/mL.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备