产品
编 号:F747861
分子式:C25H32Cl2N4
分子量:459.45
产品类型
结构图
CAS No: 1914148-73-4
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产品详情
生物活性:
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .
体内研究:
Ezurpimtrostat hydrochloride (Compound 2-3) (15 mg/kg/day,PO,持续 6 周) 显著减少 DEN 肝硬化大鼠模型中的肝纤维化面积和胶原纤维沉积水平 (降低 41.0%)。