产品
编 号：F076294
分子式：C18H17Cl3N4
分子量：395.71
分子式：C18H17Cl3N4
分子量：395.71
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CAS No: 1217049-32-5
产品详情
生物活性：
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.
体内研究：
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.Animal Model:Male C57 black mice, weighing 23-30 g
Dosage:20 mg/kg
Administration:I.p.
Result:Reversed the MPTP-induced decrease in striatal concentrations.
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.
体内研究：
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.Animal Model:Male C57 black mice, weighing 23-30 g
Dosage:20 mg/kg
Administration:I.p.
Result:Reversed the MPTP-induced decrease in striatal concentrations.
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