产品
编 号:F076232
分子式:C103H147N27O37S5
分子量:2515.75
产品类型
结构图
CAS No: 121695-87-2
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生物活性:
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels.
体内研究:
Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels.Animal Model:Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks
Dosage:1 pM-1 mM
Administration:
Result:Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident.Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.