产品
编 号：F747713
分子式：C33H37NO17
分子量：719.64
分子式：C33H37NO17
分子量：719.64
产品类型
规格
价格
是否有货
结构图
CAS No: 1884557-85-0
产品详情
生物活性：
Daunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin citrate (intravenous injection, 3 mg/kg, three times at 48 h intervals) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin citrate (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin citrate (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin citrate (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin citrate (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin citrate (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin citrate (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
Daunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin citrate (intravenous injection, 3 mg/kg, three times at 48 h intervals) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin citrate (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin citrate (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin citrate (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin citrate (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin citrate (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin citrate (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备