产品
编 号：F747690
分子式：C22H28N2O3
分子量：368.47
分子式：C22H28N2O3
分子量：368.47
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 188125-42-0
产品详情
生物活性：
Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse. Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis.
体内研究：
Zolunicant (18-MC；静脉注射；每天 0-20 μg；14 天) 通过阻断缰核-脚间通路中的 α3β4 烟碱受体来减少吗啡的自我给药。Animal Model:Na?ve female Long-Evans derived rats
Dosage:0,10 and 20 μg
Administration:Intravenous administration; once a day; 14 days
Result:Infused into the medial habenula and interpeduncular nucleus decreased morphine self-administration (interpeduncular nucleus: F(5,29) = 6.89, P < 0.0001; medial habenula: F(4,28) = 3.07, P < 0.03).
体外研究：
Zolunicant (18-MC; 0.01-100 μM) 对烟碱型 α3β4 受体具有抑制活性，IC50 为 0.90 μM。。Zolunicant (18-MCOR; 0-20 μg/mL; 24 h) 还对 L. amazonensis 感染的巨噬细胞显示出抗鞭毛体活性。
Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse. Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis.
体内研究：
Zolunicant (18-MC；静脉注射；每天 0-20 μg；14 天) 通过阻断缰核-脚间通路中的 α3β4 烟碱受体来减少吗啡的自我给药。Animal Model:Na?ve female Long-Evans derived rats
Dosage:0,10 and 20 μg
Administration:Intravenous administration; once a day; 14 days
Result:Infused into the medial habenula and interpeduncular nucleus decreased morphine self-administration (interpeduncular nucleus: F(5,29) = 6.89, P < 0.0001; medial habenula: F(4,28) = 3.07, P < 0.03).
体外研究：
Zolunicant (18-MC; 0.01-100 μM) 对烟碱型 α3β4 受体具有抑制活性，IC50 为 0.90 μM。。Zolunicant (18-MCOR; 0-20 μg/mL; 24 h) 还对 L. amazonensis 感染的巨噬细胞显示出抗鞭毛体活性。
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