产品
编 号：F747674
分子式：C25H28ClN3O5
分子量：485.96
分子式：C25H28ClN3O5
分子量：485.96
产品类型
规格
价格
是否有货
结构图
CAS No: 187793-52-8
产品详情
生物活性：
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.
体内研究：
T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.Animal Model:Rats bearing Walker-256 carcinoma
Dosage:1, 10, and 100 mg/kg
Administration:
Result:The ED50 was 23 mg/kg.
体外研究：
SN-38 is the metabolite of T-2513 hydrochloride.T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines.
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.
体内研究：
T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.Animal Model:Rats bearing Walker-256 carcinoma
Dosage:1, 10, and 100 mg/kg
Administration:
Result:The ED50 was 23 mg/kg.
体外研究：
SN-38 is the metabolite of T-2513 hydrochloride.T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines.
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