产品
编 号:F747591
分子式:C19H22ClN7O3
分子量:431.88
产品类型
结构图
CAS No: 1858291-14-1
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生物活性:
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling.