产品
编 号：F747570
分子式：C21H15ClN2O4
分子量：394.81
分子式：C21H15ClN2O4
分子量：394.81
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 185351-23-9
产品详情
生物活性：
Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
体内研究：
Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau.Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29.Animal Model:Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elavc155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control.
Dosage:0.75 mg/mL.
Administration:Dripped every other day.
Result:Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).
体外研究：
Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils.Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers.
Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.
体内研究：
Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau.Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29.Animal Model:Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elavc155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control.
Dosage:0.75 mg/mL.
Administration:Dripped every other day.
Result:Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).
体外研究：
Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils.Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers.
产品资料
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