产品
编 号：F747504
分子式：C19H32ClNO
分子量：325.92
分子式：C19H32ClNO
分子量：325.92
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 1841409-92-4
产品详情
生物活性：
SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity.
体内研究：
SH-BC-893（口服；120 mg/kg；单次）强烈而敏锐地阻断神经酰胺诱导的线粒体功能障碍，纠正饮食诱导的肥胖及其代谢后遗症。Animal Model:C57BL/6J mice (Male)
Dosage:120 mg/kg
Administration:Oral; single
Result:Blocked palmitate- and ceramide-induced mitochondrial fission, preserved mitochondrial function, and prevented ER stress.Normalized mitochondrial morphology in the livers and brains of HFD-fed mice, improved mitochondrial function in white adipose tissue, and corrected aberrant plasma leptin and adiponectin levels.Restored normal body weight, glucose disposal, and hepatic lipid levels in mice consuming a HFD.
体外研究：
SH-BC-893 通过下调细胞表面营养转运蛋白和阻断溶酶体运输事件来饿死癌细胞。SH-BC-893（5 μM；3 小时）通过破坏细胞内运输来防止神经酰胺诱导的线粒体网络断裂。SH-BC-893（8.935 nM；3 小时）防止神经酰胺诱导的线粒体功能障碍。
SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity.
体内研究：
SH-BC-893（口服；120 mg/kg；单次）强烈而敏锐地阻断神经酰胺诱导的线粒体功能障碍，纠正饮食诱导的肥胖及其代谢后遗症。Animal Model:C57BL/6J mice (Male)
Dosage:120 mg/kg
Administration:Oral; single
Result:Blocked palmitate- and ceramide-induced mitochondrial fission, preserved mitochondrial function, and prevented ER stress.Normalized mitochondrial morphology in the livers and brains of HFD-fed mice, improved mitochondrial function in white adipose tissue, and corrected aberrant plasma leptin and adiponectin levels.Restored normal body weight, glucose disposal, and hepatic lipid levels in mice consuming a HFD.
体外研究：
SH-BC-893 通过下调细胞表面营养转运蛋白和阻断溶酶体运输事件来饿死癌细胞。SH-BC-893（5 μM；3 小时）通过破坏细胞内运输来防止神经酰胺诱导的线粒体网络断裂。SH-BC-893（8.935 nM；3 小时）防止神经酰胺诱导的线粒体功能障碍。
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