产品
编 号：F747487
分子式：C56H95N25O14S
分子量：1374.58
分子式：C56H95N25O14S
分子量：1374.58
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 183623-03-2
产品详情
生物活性：
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses.
体内研究：
hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits.hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice.Animal Model:Rabbits inoculated with CFU MRSA
Dosage:20 mg/kg
Administration:Injected into the debrided tibial cavity
Result:Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.
Animal Model:Neutropenic mice challenged i.v. with C. albicans
Dosage:40 μg/kg
Administration:Intravenous injection (i.v)
Result:Reduced serum TNFα and IL-6 in infected mice.
体外研究：
hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation.hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity.hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes.hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans.
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses.
体内研究：
hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits.hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice.Animal Model:Rabbits inoculated with CFU MRSA
Dosage:20 mg/kg
Administration:Injected into the debrided tibial cavity
Result:Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.
Animal Model:Neutropenic mice challenged i.v. with C. albicans
Dosage:40 μg/kg
Administration:Intravenous injection (i.v)
Result:Reduced serum TNFα and IL-6 in infected mice.
体外研究：
hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation.hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity.hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes.hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans.
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