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编 号：F747389
分子式：C18H34O3
分子量：298.46
分子式：C18H34O3
分子量：298.46
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CAS No: 182370-45-2
产品详情
生物活性：
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.
体内研究：
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days.Animal Model:Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells
Dosage:400 mg/kg
Administration:p.o.; daily; for 21 days
Result:Caused a reduction in tumor volume of about 20-25% after 21 days.
体外研究：
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC50 of 252 μM.
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.
体内研究：
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days.Animal Model:Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells
Dosage:400 mg/kg
Administration:p.o.; daily; for 21 days
Result:Caused a reduction in tumor volume of about 20-25% after 21 days.
体外研究：
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC50 of 252 μM.
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