产品
编 号：F747311
分子式：C32H48BrN3O4
分子量：618.65
分子式：C32H48BrN3O4
分子量：618.65
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1817841-22-7
产品详情
生物活性：
MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects.
体内研究：
MeTC7 (compound 5) (i.p.; 10 mg/kg) reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.Animal Model:Mice
Dosage:10 mg/kg
Administration:IP
Result:Reduced the growth of xenografts derived from ovarian cancer, medulloblastoma, and pancreatic cancer cells.Inhibited the growth of neuroblastoma cells and Xenografts.Reduced MYCN expression and blocked the growth of TH-MYCN transgene-driven spontaneous neuroblastoma.
体外研究：
MeTC7 (compound 5) shows potent VDR inhibition activity with an IC50 value of 2.9 μM.MeTC7 disrupts the VDR-Ligand-binding domain in Silico.MeTC7 (250 nM; 18 h) suppresses RXRα and Importin-4 expressions in the ovarian cancer cell-line.MeTC7 (250 nM; 18 h) inhibits the viability of ovarian cancer cells and induces PARP1 cleavage.
MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects.
体内研究：
MeTC7 (compound 5) (i.p.; 10 mg/kg) reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.Animal Model:Mice
Dosage:10 mg/kg
Administration:IP
Result:Reduced the growth of xenografts derived from ovarian cancer, medulloblastoma, and pancreatic cancer cells.Inhibited the growth of neuroblastoma cells and Xenografts.Reduced MYCN expression and blocked the growth of TH-MYCN transgene-driven spontaneous neuroblastoma.
体外研究：
MeTC7 (compound 5) shows potent VDR inhibition activity with an IC50 value of 2.9 μM.MeTC7 disrupts the VDR-Ligand-binding domain in Silico.MeTC7 (250 nM; 18 h) suppresses RXRα and Importin-4 expressions in the ovarian cancer cell-line.MeTC7 (250 nM; 18 h) inhibits the viability of ovarian cancer cells and induces PARP1 cleavage.
产品资料
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