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编 号：F747310
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CAS No: 1817821-77-4
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ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.
体内研究：
ODN MT01 抑制牙周炎大鼠牙槽骨丢失，诱导骨组织OPG和Osterix蛋白产生。
体外研究：
ODN MT01 可促进BMSCs增殖、向成骨细胞分化，并促进Runx2、Osterix、OPG、RANKL和collagen I的mRNA表达。。ODN MT01 影响 MG63 细胞的细胞周期，促进细胞增殖。
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.
体内研究：
ODN MT01 抑制牙周炎大鼠牙槽骨丢失，诱导骨组织OPG和Osterix蛋白产生。
体外研究：
ODN MT01 可促进BMSCs增殖、向成骨细胞分化，并促进Runx2、Osterix、OPG、RANKL和collagen I的mRNA表达。。ODN MT01 影响 MG63 细胞的细胞周期，促进细胞增殖。
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