产品
编 号:F009453
分子式:C29H24ClN3O3S
分子量:530.04
产品类型
结构图
CAS No: 1019331-10-2
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产品详情
生物活性:
S0859 is a selective, high-affinity generic Na+/HCO3- transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
体外研究:
Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.