产品
编 号：F747200
分子式：C27H20N8O
分子量：472.5
分子式：C27H20N8O
分子量：472.5
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CAS No: 1804127-83-0
产品详情
生物活性：
CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.
体外研究：
CDK9-IN-18 (compound 12i) (0-20 μM, 3 hours; NH2 cells) suppress both HIV-1 transcription and the phosphorylation at Serine 2 of the RNAPII CTD in a dose-dependent manner.CDK9-IN-18 (compound 12i) (0-5.0 μM, 24 hours; human tumor cell lines) exerts antiproliferative effect through the induction of apoptosis in HepG2 cells.
CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.
体外研究：
CDK9-IN-18 (compound 12i) (0-20 μM, 3 hours; NH2 cells) suppress both HIV-1 transcription and the phosphorylation at Serine 2 of the RNAPII CTD in a dose-dependent manner.CDK9-IN-18 (compound 12i) (0-5.0 μM, 24 hours; human tumor cell lines) exerts antiproliferative effect through the induction of apoptosis in HepG2 cells.
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