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编 号：F747188
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1mg
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CAS No: 1803176-05-7
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生物活性：
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.
体内研究：
Oleclumab (10 mg/kg; ip; 每 3 天一次，共 4 次) 在小鼠 Balb/c 同基因 CT26 结肠癌肿瘤模型中，增加活化 CD8S+ 淋巴细胞群的比例，并显著抑制肿瘤生长。Animal Model:Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model
Dosage:10 mg/kg
Administration:ip; 2 time per week, for 2 weeks
Result:Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.
体内研究：
Oleclumab (10 mg/kg; ip; 每 3 天一次，共 4 次) 在小鼠 Balb/c 同基因 CT26 结肠癌肿瘤模型中，增加活化 CD8S+ 淋巴细胞群的比例，并显著抑制肿瘤生长。Animal Model:Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model
Dosage:10 mg/kg
Administration:ip; 2 time per week, for 2 weeks
Result:Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
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