产品
编 号：F747169
分子式：C20H20N4
分子量：316.4
分子式：C20H20N4
分子量：316.4
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CAS No: 1802703-20-3
产品详情
生物活性：
AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50?of 11 nM. AAK1-IN-3 has the?potential?for?neuropathic pain research.
体内研究：
AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice.
体外研究：
AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM).
AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50?of 11 nM. AAK1-IN-3 has the?potential?for?neuropathic pain research.
体内研究：
AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice.
体外研究：
AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM).
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