产品
编 号：F747155
分子式：C35H55N11O9
分子量：773.88
分子式：C35H55N11O9
分子量：773.88
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结构图
CAS No: 1801959-12-5
产品详情
生物活性：
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
体内研究：
PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property.Animal Model:Na?ve male C57Bl/6J mice
Dosage:3.0μg/kg
Administration:Intraperitoneal
Result:Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
体外研究：
PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM.
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.
体内研究：
PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property.Animal Model:Na?ve male C57Bl/6J mice
Dosage:3.0μg/kg
Administration:Intraperitoneal
Result:Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
体外研究：
PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM.
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