产品
编 号：F747130
分子式：C31H30FNO3
分子量：483.57
分子式：C31H30FNO3
分子量：483.57
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1801185-08-9
产品详情
生物活性：
SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research.
体内研究：
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis.SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis.Animal Model:C57BL/6 mice inducing experimental autoimmune encephalomyelitis (EAE)
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; twice a day
Result:Diminished the incidence of disease with approximately 20% mice developing disease.Showed no overt signs of toxicity.
Animal Model:PLP139-151-induced relapsing-remitting EAE (R-EAE) in SJL/J mice
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization
Result:Resulted in a significant reduction in the relapse severity compared to the vehicle control.Showed a significant decrease in the frequency and number of CD4+ and CD8+ effector cells (CD44hi).
体外研究：
SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells.SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions.
SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research.
体内研究：
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis.SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis.Animal Model:C57BL/6 mice inducing experimental autoimmune encephalomyelitis (EAE)
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; twice a day
Result:Diminished the incidence of disease with approximately 20% mice developing disease.Showed no overt signs of toxicity.
Animal Model:PLP139-151-induced relapsing-remitting EAE (R-EAE) in SJL/J mice
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization
Result:Resulted in a significant reduction in the relapse severity compared to the vehicle control.Showed a significant decrease in the frequency and number of CD4+ and CD8+ effector cells (CD44hi).
体外研究：
SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells.SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions.
产品资料
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